‘red rag’—a piece of red cloth used to provoke an animal—hence, figuratively, a source of provocation or annoyance, something which excites violent indignation—the notion occurs in the late 16th century
1546—originally designated the period of time following a wedding, and arose from the comparison of the mutual affection of newly-married persons to the changing moon, which is no sooner full than it begins to wane
16th century—exclamation of annoyance at the reappearance of someone or something—from bear-leaders’ regular visits or from story of Elisha and the bears